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Journal: eBioMedicine
Article Title: Genomic profiling and associated B cell lineages delineate the efficacy of neoadjuvant anti-PD-1-based therapy in oesophageal squamous cell carcinoma
doi: 10.1016/j.ebiom.2024.104971
Figure Lengend Snippet: Immune infiltration heterogeneity of ESCC with distinct therapeutic responses. (a) UMAP plot showing clustering for immune cells from 10 patients with ESCC (left), expression of selected genes (middle) and distribution according to different therapeutic responses (right). (b) Dot plot showing the expression of PDCD1 and CD274 in immune cell clusters from responders and non-responders. (c) Lollipop chart showing difference of proportions of immune cell clusters in patients with different MMR status (left) and therapeutic responses (right) (scales of circles indicate the –log P value; Student's t test). (d) Expression heatmap of signature genes in distinct lymphocyte clusters. (e) UMAP plot showing the subclustering for CD4 + T cells from 10 patients with ESCC (left), expression of selected genes (middle) and distribution in different therapeutic responses (right). (f) Lollipop chart showing differences of proportions of CD4 + T cell subclusters from patients with different MMR status (left) and therapeutic responses (right) (scales of circles indicate the –log P value; Student's t test). (g) UMAP plot showing the subclustering for B cells from 10 patients with ESCC (left), expression of selected genes (middle) and distribution according to different therapeutic responses (right). (h) Lollipop and column chart showing difference of proportions of B cell subclusters from patients with different MMR status (scales of circles indicate the –log P value; Student's t test; left) and therapeutic responses (Chi-square test; right). P values are indicated in the figure.
Article Snippet: Immune infiltration heterogeneity of ESCC with distinct therapeutic responses. (a) UMAP plot showing clustering for immune cells from 10 patients with ESCC (left), expression of selected genes (middle) and distribution according to different therapeutic responses (right). (b) Dot plot showing the expression of PDCD1 and CD274 in immune cell clusters from responders and non-responders. (c) Lollipop chart showing difference of proportions of immune cell clusters in patients with different MMR status (left) and therapeutic responses (right) (scales of circles indicate the –log P value; Student's t test). (d) Expression heatmap of signature genes in distinct lymphocyte clusters. (e) UMAP plot showing the subclustering for CD4 + T cells from 10 patients with ESCC (left), expression of selected genes (middle) and distribution in different therapeutic responses (right). (f) Lollipop chart showing differences of proportions of CD4 + T cell subclusters from patients with different MMR status (left) and therapeutic responses (right) (scales of circles indicate the –log P value; Student's t test). (g)
Techniques: Expressing